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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF4E
All Species:
42.12
Human Site:
T55
Identified Species:
57.92
UniProt:
P06730
Number Species:
16
Phosphosite Substitution
Charge Score:
-0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P06730
NP_001959.1
217
25097
T55
F
K
N
D
K
S
K
T
W
Q
A
N
L
R
L
Chimpanzee
Pan troglodytes
XP_523824
217
24938
T55
F
K
N
D
K
S
K
T
S
Q
A
N
L
W
L
Rhesus Macaque
Macaca mulatta
XP_001092045
253
28850
A91
F
K
N
D
R
S
R
A
W
Q
D
N
L
H
L
Dog
Lupus familis
XP_544992
217
25075
T55
F
K
N
D
K
S
K
T
W
Q
A
N
L
R
L
Cat
Felis silvestris
Mouse
Mus musculus
Q3UTA9
244
27967
A83
F
K
N
D
R
S
R
A
W
Q
D
N
L
Q
L
Rat
Rattus norvegicus
P63074
217
25035
T55
F
K
N
D
K
S
K
T
W
Q
A
N
L
R
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514651
236
27161
T64
T
S
S
A
N
E
S
T
T
T
P
N
P
Q
P
Chicken
Gallus gallus
XP_420655
217
25026
T55
F
K
N
D
K
S
K
T
W
Q
A
N
L
R
L
Frog
Xenopus laevis
P48597
213
24616
T51
F
K
N
D
K
S
K
T
W
Q
A
N
L
R
L
Zebra Danio
Brachydanio rerio
Q9DFS6
215
24831
T53
F
K
N
D
K
S
K
T
W
Q
A
N
L
R
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48598
259
29205
S99
L
E
N
D
R
S
K
S
W
E
D
M
Q
N
E
Honey Bee
Apis mellifera
XP_624290
213
24784
T51
Y
E
P
D
R
N
K
T
W
E
E
S
Q
R
K
Nematode Worm
Caenorhab. elegans
O61955
248
27791
K56
K
E
W
E
D
C
L
K
M
V
S
L
F
D
T
Sea Urchin
Strong. purpuratus
NP_001091928
225
25645
S63
F
K
N
D
K
A
K
S
W
T
E
N
L
R
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O81481
218
24452
A64
Q
S
K
S
K
Q
A
A
W
G
S
S
I
R
P
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O23252
235
26501
S81
A
V
K
S
K
Q
T
S
W
G
S
S
L
R
P
Baker's Yeast
Sacchar. cerevisiae
P07260
213
24236
S57
P
A
V
D
K
S
E
S
W
S
D
L
L
R
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.6
59.2
99.5
N.A.
53.2
98.1
N.A.
71.6
92.1
88.4
82.9
N.A.
43.6
54.8
41.1
53.7
Protein Similarity:
100
98.6
69.1
99.5
N.A.
69.2
98.6
N.A.
74.1
94
94
92.6
N.A.
56.3
68.6
58.8
73.7
P-Site Identity:
100
86.6
66.6
100
N.A.
66.6
100
N.A.
13.3
100
100
100
N.A.
33.3
33.3
0
66.6
P-Site Similarity:
100
86.6
80
100
N.A.
86.6
100
N.A.
26.6
100
100
100
N.A.
60
73.3
20
80
Percent
Protein Identity:
N.A.
42.2
N.A.
39.5
31.8
N.A.
Protein Similarity:
N.A.
56.8
N.A.
54
55.3
N.A.
P-Site Identity:
N.A.
20
N.A.
26.6
40
N.A.
P-Site Similarity:
N.A.
40
N.A.
46.6
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
6
6
0
6
0
6
6
18
0
0
42
0
0
0
0
% A
% Cys:
0
0
0
0
0
6
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
77
6
0
0
0
0
0
24
0
0
6
0
% D
% Glu:
0
18
0
6
0
6
6
0
0
12
12
0
0
0
6
% E
% Phe:
59
0
0
0
0
0
0
0
0
0
0
0
6
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
12
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
6
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
6
0
0
% I
% Lys:
6
59
12
0
65
0
59
6
0
0
0
0
0
0
6
% K
% Leu:
6
0
0
0
0
0
6
0
0
0
0
12
71
0
53
% L
% Met:
0
0
0
0
0
0
0
0
6
0
0
6
0
0
0
% M
% Asn:
0
0
65
0
6
6
0
0
0
0
0
65
0
6
0
% N
% Pro:
6
0
6
0
0
0
0
0
0
0
6
0
6
0
24
% P
% Gln:
6
0
0
0
0
12
0
0
0
53
0
0
12
12
0
% Q
% Arg:
0
0
0
0
24
0
12
0
0
0
0
0
0
65
0
% R
% Ser:
0
12
6
12
0
65
6
24
6
6
18
18
0
0
0
% S
% Thr:
6
0
0
0
0
0
6
53
6
12
0
0
0
0
12
% T
% Val:
0
6
6
0
0
0
0
0
0
6
0
0
0
0
0
% V
% Trp:
0
0
6
0
0
0
0
0
83
0
0
0
0
6
0
% W
% Tyr:
6
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _